Oxidative Ionic Metabolites of 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine (MPTP): Correlation of Electroreduction with Physiological Behavior
Free Radical Biology and Medicine
Electrochemical studies (reduction potential and reversibility) were performed on 1-methyl-4-phenylpyridinium (MPP+) and 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). MPP+ gave reduction potentials in the range of -1.09 to -1.11 V in organic solvents in a process which was reversible. The reduction potential of MPDP+ was -0.64 V (irreversible). Possible relationships involving the electrochemical properties, oxy radical formation, and biological activity of these and related iminium species are discussed.
Ames, James R.; Castagnoli, N. Jr.; Ryan, Michael D.; and Kovacic, Peter, "Oxidative Ionic Metabolites of 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine (MPTP): Correlation of Electroreduction with Physiological Behavior" (1986). Chemistry Faculty Research and Publications. 442.