Mode of Action of Antiprotozoan Agents. Electron Transfer and Oxy Radicals
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Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocyles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of −0.3 to −0.9 V. Catalytic production of oxidative pressure from redox cycling involving oxygen is believed to be an important mode of action by the medicinal agents. Literature data contribute support.