Oxygen Activation by Mononuclear Mn, Co, and Ni Centers in Biology and Synthetic Complexes

Authors

Adam T. Fiedler, Marquette UniversityFollow
Anne A. Fischer, Marquette University

Document Type

Article

Language

eng

Publication Date

4-2017

Publisher

Springer

Source Publication

Journal of Biological Inorganic Chemistry

Source ISSN

0949-8257

Abstract

The active sites of metalloenzymes that catalyze O₂-dependent reactions generally contain iron or copper ions. However, several enzymes are capable of activating O₂ at manganese or nickel centers instead, and a handful of dioxygenases exhibit activity when substituted with cobalt. This minireview summarizes the catalytic properties of oxygenases and oxidases with mononuclear Mn, Co, or Ni active sites, including oxalate-degrading oxidases, catechol dioxygenases, and quercetin dioxygenase. In addition, recent developments in the O₂ reactivity of synthetic Mn, Co, or Ni complexes are described, with an emphasis on the nature of reactive intermediates featuring superoxo-, peroxo-, or oxo-ligands. Collectively, the biochemical and synthetic studies discussed herein reveal the possibilities and limitations of O₂ activation at these three “overlooked” metals.

Comments

Accepted version. Journal of Biological Inorganic Chemistry, Vol. 22, No. 2-3 (April 2017): 407-424. DOI. © 2017 Springer International Publishing AG. Part of Springer Nature. Used with permission.

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Recommended Citation

Fiedler, Adam T. and Fischer, Anne A., "Oxygen Activation by Mononuclear Mn, Co, and Ni Centers in Biology and Synthetic Complexes" (2017). Chemistry Faculty Research and Publications. 535.
https://epublications.marquette.edu/chem_fac/535