Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines

Authors

Peter Kovacic, University of Wisconsin - Milwaukee
James R. Ames, University of Wisconsin - Milwaukee
Michael D. Ryan, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

8-1987

Publisher

Cognizant Communication Corporation

Source Publication

Anti-Cancer Drug Design

Source ISSN

0266-9536

Abstract

A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm. Cyclic voltammetry was performed on iminium type ions derived by protonation of the acridines. Reductions were generally reversible with potentials of about - 0.60 V. Involvement of quinoidal metabolites is also a possibility. The relationship of electrochemical behavior to structure and physiological activity is addressed.

Comments

Published version. Anti-Cancer Drug Design, Vol. 2, No. 1 (August 1987): 37-46. Publisher link. © 1986 Cognizant Communication Corporation. Used with permission.

Recommended Citation

Kovacic, Peter; Ames, James R.; and Ryan, Michael D., "Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines" (1987). Chemistry Faculty Research and Publications. 601.
https://epublications.marquette.edu/chem_fac/601