The Sequence of a Stepwise AdE Reaction and Intramolecular Pauson-Khand Cycloaddition as an Entry into the Synthesis of Polycyclic Compounds

Authors

A. S. Gybin, Zelinsky Institute of Organic Chemistry
W. A. Smit, Zelinsky Institute of Organic Chemistry
R. Caple, University of Minnesotat - Duluth
A. L. Veretenov, Zelinsky Institute of Organic Chemistry
A. S. Shashkov, Zelinsky Institute of Organic Chemistry
L. G. Vorontsova, Zelinsky Institute of Organic Chemistry
M. G. Kurella, Zelinsky Institute of Organic Chemistry
V. S. Chertkov, Moscow State University
A. A. Carapetyan, Nesmeyanov Institute of Organoelement Compounds
A. Yu. Kosnikov, Nesmeyanov Institute of Organoelement Compounds
Mikael S. Alexanyan, Nesmeyanov Institute of Organoelement Compounds
Sergey Lindeman, Marquette UniversityFollow
V. N. Panov, Nesmeyanov Institute of Organoelement Compounds
A. V. Maleev, Nesmeyanov Institute of Organoelement Compounds
Yuri T. Struchkov, Nesmeyanov Institute of Organoelement Compounds
S. M. Sharpe, University of Minnesota - Duluth

Document Type

Article

Language

eng

Publication Date

1992

Publisher

American Chemical Society

Source Publication

Journal of the American Chemical Society

Source ISSN

0002-7863

Abstract

A stepwise AdE acylmethoxylation across the double bond of dicobalt hexacarbonyl complexes (DCHCC) of conjugated enynes was elaborated as an efficient and general route for the synthesis of DCHCC of 1,6-enynes containing a combination of five- and six-membered-ring fragments. Depending on the structure of these adducts, the latter either were subjected to 1,2-carbnyl reduction followed by an intramolecular Pauson-Khand (IMPK) cyclization or were directly utilized as substrates for this process. A list of model polycyclic systems which were assembled using this approach includes [5.5.5] angularly fused compounds, [6.5.5] and [5.5.5] linearly fused tricyclics, and linearly and angularly fused [6.5.5.5] and [5.5.5.5] tetracyclic products. A novel convergent and general method for the synthesis of various cyclic compounds is suggested on the basis of the AdE-IMPK tandem sequence as the key steps for the assemblage of polycyclic frameworks. This option seems to be especially promising for the tetracyclic derivatives mentioned above, as in these cases only two operationally simple steps are required to convert read:'-/ available starting blocks into the target structures related to natural polyquinanes.

Comments

Journal of the American Chemical Society, Vol. 114, No. 14 (1992)L 5555-5566. DOI.

Sergey Lindeman was affiliated with Nesmeyanov Institute of Organoelement Compounds at the time of publication.

Recommended Citation

Gybin, A. S.; Smit, W. A.; Caple, R.; Veretenov, A. L.; Shashkov, A. S.; Vorontsova, L. G.; Kurella, M. G.; Chertkov, V. S.; Carapetyan, A. A.; Kosnikov, A. Yu.; Alexanyan, Mikael S.; Lindeman, Sergey; Panov, V. N.; Maleev, A. V.; Struchkov, Yuri T.; and Sharpe, S. M., "The Sequence of a Stepwise AdE Reaction and Intramolecular Pauson-Khand Cycloaddition as an Entry into the Synthesis of Polycyclic Compounds" (1992). Chemistry Faculty Research and Publications. 713.
https://epublications.marquette.edu/chem_fac/713