A Synthetic Model of the Nonheme Iron–Superoxo Intermediate of Cysteine Dioxygenase

Authors

Anne A. Fischer, Marquette University
Sergey V. Lindeman, Marquette UniversityFollow
Adam T. Fiedler, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

9-24-2018

Publisher

Royal Society of Chemistry

Source Publication

Chemical Communications

Source ISSN

1359-7345

Abstract

A nonheme Fe(II) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O₂ at −80 °C to yield a purple intermediate (2). Analysis with spectroscopic and computational methods determined that 2 features a thiolate-ligated Fe(III) center bound to a superoxide radical, mimicking the putative structure of a key CDO intermediate.

Comments

Accepted version. Chemical Communications, Vol. 54, (2018): 11344-11347. DOI. © 2018 The Royal Society of Chemistry. Used with permission.

Recommended Citation

Fischer, Anne A.; Lindeman, Sergey V.; and Fiedler, Adam T., "A Synthetic Model of the Nonheme Iron–Superoxo Intermediate of Cysteine Dioxygenase" (2018). Chemistry Faculty Research and Publications. 961.
https://epublications.marquette.edu/chem_fac/961