Grant Title
Natural Products Synthesis via Organoiron Methodology
Document Type
Spectral Data
Format Type
Publication Date
2-2013
Abstract
Spectral data created in the course of the research project. Supports specific findings in "Generation of Molecular Complexity from Cyclooctatetraene: Preparation of Optically Active Protected Aminocycloheptitols and Bicyclo[4.4.1]undecatriene".
The racemic (6-cyclo-heptadienyl)Fe(CO)3+ cation ((±)-7), prepared from cyclooctatetraene, was treated with a variety of carbon and heteroatom nucleophiles. Attack took place at the less hindered C1 dienyl carbon and decomplexation of the (cycloheptadiene)Fe(CO)3 complexes gave products rich in functionality for further synthetic manipulation. In particular, a seven-step route was developed from racemic (6-styryl-2,4-cycloheptadien-1-yl)phthalimide ((±)-9 d) to afford the optically active aminocycloheptitols (−)-20 and (+)-20.
Recommended Citation
El-Mansy, Mohamed F.; Sar, Anobick; Lindeman, Sergey V.; and Donaldson, William A., "Spectral Data for "Generation of Molecular Complexity from Cyclooctatetraene: Preparation of Optically Active Protected Aminocycloheptitols and Bicyclo[4.4.1]undecatriene"" (2013). Natural Products Synthesis via Organoiron Methodology. 8.
https://epublications.marquette.edu/data_nps/8