Taylor & Francis
CRANIO®: The Journal of Craniomandibular & Sleep Practice
Objective: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis.
Methods: Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples). Immunostaining of the TMJ discs was statistically compared between the groups.
Results: There was no statistically significant difference for the area of MMP-13 immunostaining between the control group, ADDwR, and ADDwoR, nor between groups with and without osteoarthrosis.
Conclusion: This study suggests MMP-13 is not significantly involved in collagen degradation in human TMJ disc displacement or osteoarthrosis.
Perotto, Juliano Henrique; Camejo, Flavio; Doetzer, Andrea; Almeida, Luis Eduardo; Azevedo, Marina; and Olandoski, Marcia, "Expression of MMP-13 in Human Temporomandibular Joint Disc Derangement and Osteoarthritis" (2017). School of Dentistry Faculty Research and Publications. 257.