Document Type
Article
Language
eng
Publication Date
4-2018
Publisher
Taylor & Francis
Source Publication
CRANO: Journal of Craniomandibular & Sleep Practice
Source ISSN
0886-9634
Abstract
Objective
Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD). The purpose of this study was to histologically examine the level of expression of TLR-4 relative to severity of TMD.
Methods
Thirty-one human TMJ disc samples were immunostained for TLR-4 and evaluated for intensity of stain. Among the samples, 8 were control samples, 16 were from patients with anterior disc displacement with reduction (ADDwR), and 7 were from patients with anterior disc displacement without reduction (ADDwoR).
Results
There was no statistically significant difference in intensity of stain between groupings (p = 0.673).
Conclusions
The results indicate a negative correlation between TMD and the expression of TLR-4.
Recommended Citation
Almeida, Luis Eduardo; Hresko, Kyle; Sorenson, Adam; Butcher, Seth; Tayebi, Lobat; Leonardi, Rosalia; Loreto, Carla; Bosio, Jose A.; Camejo, Flavio; and Doetzer, Andrea, "Immunohistochemical Expression of TLR-4 in Temporomandibular Joint Dysfunction" (2018). School of Dentistry Faculty Research and Publications. 269.
https://epublications.marquette.edu/dentistry_fac/269
Comments
Accepted version. CRANIO: The Journal of Craniomandibular & Sleep Practice, (2018). DOI. © 2018 Taylor & Francis. Used with permission.