Expression of Interleukin-1 and Temporomandibular Disorder: Contemporary Review of the Literature

Authors

Adam Sorenson, Marquette University
Kyle Hresko, Marquette University
Seth Butcher, Marquette University
Sean Pierce, University of California - Los AngelesFollow
Vinícius Augusto Tramontina, Pontifical University of ParanáFollow
Rosalia Leonardi, University of Catania
Carla Loreto, University of Catania
Jose A. Bosio, Marquette UniversityFollow
Luis Eduardo Almeida, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

2017

Publisher

Taylor & Francis

Source Publication

CRANIO®: The Journal of Craniomandibular & Sleep Practice

Source ISSN

0886-9634

Abstract

Objective: Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1.

Methods: A literature search (2006–2016) to identify eligible studies was completed using the PubMed database. Studies identified used saline irrigation to quantify cytokine profiles in synovial fluid of healthy and/or dysfunctional joints.

Results: The initial search yielded 111 articles, 5 of which met the inclusion criteria after inter-reviewer discussion.

Conclusions: Articles that compared IL-1 concentrations in TMD vs. control groups found significant differences.

Comments

Accepted version. CRANIO®: The Journal of Craniomandibular & Sleep Practice, (2017). DOI. © 2017 Taylor & Francis. Used with permission.

Recommended Citation

Sorenson, Adam; Hresko, Kyle; Butcher, Seth; Pierce, Sean; Tramontina, Vinícius Augusto; Leonardi, Rosalia; Loreto, Carla; Bosio, Jose A.; and Almeida, Luis Eduardo, "Expression of Interleukin-1 and Temporomandibular Disorder: Contemporary Review of the Literature" (2017). School of Dentistry Faculty Research and Publications. 297.
https://epublications.marquette.edu/dentistry_fac/297