Document Type

Article

Language

eng

Publication Date

7-2019

Publisher

Elsevier

Source Publication

Acta Biomaterialia

Source ISSN

1742-7061

Abstract

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. This review aims to provide an introduction to nanogels, their preparation methods, and to discuss the design of various stimulus-responsive nanogels that are able to provide controlled drug release in response to particular stimuli.

Comments

Accepted version. Acta Biomaterialia, Vol. 92 (July 2019): 1-18. DOI. This article is © Elsevier. Used with permission.

Available for download on Thursday, July 01, 2021

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