Document Type
Article
Language
eng
Publication Date
10-2019
Publisher
Elsevier
Source Publication
Materials Science and Engineering : C
Source ISSN
0928-4931
Abstract
This paper describes the design of stimuli-sensitive theranostic nanoparticles, composed of reduced graphene oxide (rGO) self-assembled on thermosensitive liposomes encapsulated doxorubicin (DOX) and carbon quantum dot (CQD) (CQD-DOX-rGO-Tlip). The rGO-Tlip particles have been observed to be flower-shaped objects. The thermoresponsive and theranostic potential of CQD-DOX-rGO-Tlips have been studied using differential scanning calorimetry (DSC), ultraviolet visible spectroscopy (UV–Vis), Raman spectroscopy and photoluminescent assays. The chemo-photothermal potential of rGO–Tlip on MD-MB-231 cells during NIR laser irradiation has been examined using MTT assay. Also, the ability of rGO–Tlip to be taken up by MD-MB-231 cells has been studied using confocal microscopy and flowcytometry. The results indicate that CQD-DOX-rGO-Tlips achieve a synergistic effect between photothermal therapy and chemotherapy for cancer treatment. Furthermore, online monitoring drug release is accomplished by studying the emission intensity of CQD while DOX released.
Recommended Citation
Hashemi, Mohadeseh; Mohammadi, Javad; Omidi, Meisam; Smyth, Hugh D.C.; Muralidharan, Bharadwaj; Milner, Thomas E.; Yadegari, Amir; Ahmadvand, Davoud; Shalbaf, Mohammad; and Tayebi, Lobat, "Self-Assembling of Graphene Oxide on Carbon Quantum Dot Loaded Liposomes" (2019). School of Dentistry Faculty Research and Publications. 355.
https://epublications.marquette.edu/dentistry_fac/355
Comments
Accepted version. Materials Science and Engineering : C, Vol. 103 (October 2019): 109860. DOI. © 2019 Elsevier. Used with permission.