Biomaterials Evaluation: Conceptual Refinements and Practical Reforms

Authors

Reza Masaeli, Tehran University of Medical Sciences
Kavosh Zandsalimi, University of Tehran
Lobat Tayebi, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

2019

Publisher

SAGE Publications

Source Publication

Therapeutic Innovation & Regulatory Science

Source ISSN

2168-4790

Abstract

Regarding the widespread and ever-increasing applications of biomaterials in different medical fields, their accurate assessment is of great importance. Hence the safety and efficacy of biomaterials is confirmed only through the evaluation process, the way it is done has direct effects on public health. Although every biomaterial undergoes rigorous premarket evaluation, the regulatory agencies receive a considerable number of complications and adverse event reports annually. The main factors that challenge the process of biomaterials evaluation are dissimilar regulations, asynchrony of biomaterials evaluation and biomaterials development, inherent biases of postmarketing data, and cost and timing issues. Several pieces of evidence indicate that current medical device regulations need to be improved so that they can be used more effectively in the evaluation of biomaterials. This article provides suggested conceptual refinements and practical reforms to increase the efficiency and effectiveness of the existing regulations. The main focus of the article is on strategies for evaluating biomaterials in US, and then in EU.

Comments

Accepted version. Therapeutic Innovation & Regulatory Science, Vol. 53, No. 1 (2019): 120-127. DOI. © 2019 SAGE Publications. Used with permission.

Recommended Citation

Masaeli, Reza; Zandsalimi, Kavosh; and Tayebi, Lobat, "Biomaterials Evaluation: Conceptual Refinements and Practical Reforms" (2019). School of Dentistry Faculty Research and Publications. 363.
https://epublications.marquette.edu/dentistry_fac/363