Bicyclic Peptides: Types, Synthesis and Applications

Authors

Shahrzad Ahangarzadeh, Isfahan University of Medical Sciences
Mohammad M. Kanafi, Shahid Beheshti University of Medical Sciences
Simzar Hosseinzadeh, Shahid Beheshti University of Medical Sciences
Ahad Mokhtarzadeh, Tabriz University of Medical Sciences
Mahmood Barati, Iran University of Medical Sciences
Javad Ranjbari, Shahid Beheshti University of Medical Sciences
Lobat Tayebi, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

6-2019

Publisher

Elsevier

Source Publication

Drug Discovery Today

Source ISSN

1359-6446

Abstract

Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging and diagnosis. Their uses as antimicrobial agents, as well as the therapeutic functions of different bicyclic peptides, are also discussed.

Comments

Accepted version. Drug Discovery Today, Vol. 24, No. 6 (June 2019): 1311-1319. DOI. © 2019 Elsevier. Used with permission.

Recommended Citation

Ahangarzadeh, Shahrzad; Kanafi, Mohammad M.; Hosseinzadeh, Simzar; Mokhtarzadeh, Ahad; Barati, Mahmood; Ranjbari, Javad; and Tayebi, Lobat, "Bicyclic Peptides: Types, Synthesis and Applications" (2019). School of Dentistry Faculty Research and Publications. 367.
https://epublications.marquette.edu/dentistry_fac/367