Document Type

Article

Publication Date

10-2019

Publisher

Wiley

Source Publication

Journal of Cellular Physiology

Source ISSN

0021-9541

Abstract

Significant advances have been achieved in recent years to ameliorate rheumatoid arthritis (RA) in animal models using gene therapy approaches rather than biological treatments. Although biological agents serve as antirheumatic drugs with suppressing proinflammatory cytokine activities, they are usually accompanied by systemic immune suppression resulting from continuous or high systemic dose injections of biological agents. Therefore, gene transfer approaches have opened an interesting perspective to deliver one or multiple genes in a target‐specific or inducible manner for the sustained intra‐articular expression of therapeutic products. Accordingly, many studies have focused on gene transferring methods in animal models by using one of the available approaches. In this study, the important strategies used to select effective genes for RA gene therapy have been outlined. Given the work done in this field, the future looks bright for gene therapy as a new method in the clinical treatment of autoimmune diseases such as RA, and by ongoing efforts in this field, we hope to achieve feasible, safe, and effective treatment methods.

Comments

Accepted version. Journal of Cellular Physiology, Vol. 234, No. 10 (October 2019): 16913-16924. DOI. © 2019 Wiley. Used with permission.

Download
tayebi_14039acc.docx (253 kB)
ADA Accessible Version

Included in

Dentistry Commons

Share

COinS