Document Type
Article
Language
eng
Publication Date
3-2020
Publisher
PAGEPress Publications
Source Publication
European Journal of Histochemistry
Source ISSN
1121-760X
Abstract
Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.
Recommended Citation
Loreto, Carla; Filetti, Veronica; Almeida, Luis Eduardo; La Rosa, Giusy Rita Maria; Leonardi, Rosalia; Grippaudo, Cristina; and Lo Giudice, Antonino, "MMP-7 and MMP-9 Are Overexpressed in The Synovial Tissue from Severe Temporomandibular Joint Dysfunction" (2020). School of Dentistry Faculty Research and Publications. 379.
https://epublications.marquette.edu/dentistry_fac/379
Comments
Published version. European Journal of Histochemistry, Vol. 64, No. 2 (March 2020): 172-176. DOI. © 2020 PAGEPress Publications. Used with permission.