A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold with Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies

Authors

Ashkan Bigham, Isfahan University of Medical Sciences
Amir Hamed Aghajanian, Isfahan University of Medical Sciences
Mehdi Movahedi, Islamic Azad University
Mansoureh Sattary, Isfahan University of Medical Sciences
Mohammad Rafienia, Isfahan University of Medical Sciences
Lobat Tayebi, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

1-2021

Publisher

Elsevier

Source Publication

Journal of the European Ceramic Society

Source ISSN

0955-2219

Abstract

This is a comprehensive study reporting the fabrication of highly porous Gehlenite scaffold (Ca₂Al₂SiO₇)—both with and without surface modification—for the first time. The sintering temperature of Gehlenite scaffolds was optimized. Next, the optimized Gehlenite scaffold was coated by polycaprolactone (PCL)-Forsterite (Mg₂SiO₄) nanocomposite to improve the scaffold’s brittleness and biological properties. 1375 °C was found to be the optimized sintering temperature by which the Gehlenite scaffold was consolidated. Different PCL and Forsterite concentrations were separately applied on the optimized scaffold to yield a complete nanocomposite coating without clogging the macroporous structure. The bioactivity, degradation rate, cell viability, attachment and proliferation of three different scaffolds—non-coated (sintered at 1375 °C), PCL-coated and PCL/Forsterite nanocomposite-coated—were scrutinized and compared to each other in vitro. Based on our results, it is concluded that the PCL-Forsterite nanocomposite-coated scaffold with desired physical, chemical and biological-related properties has a great potential for bone tissue regeneration.

Comments

Accepted version. Journal of the European Ceramic Society, Vol. 41, No. 1 (January 2021): 941-962. DOI. © 2021 Elsevier. Used with permission.

Recommended Citation

Bigham, Ashkan; Aghajanian, Amir Hamed; Movahedi, Mehdi; Sattary, Mansoureh; Rafienia, Mohammad; and Tayebi, Lobat, "A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold with Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies" (2021). School of Dentistry Faculty Research and Publications. 403.
https://epublications.marquette.edu/dentistry_fac/403