Epidemiology of Male Breast Cancer

Authors

Santhi Konduri, Advocate Aurora Health
Maharaj Singh, Marquette UniversityFollow
George Bobustuc, Advocate Aurora Health
Richard Rovin, Advocate Aurora Health
Amin Kassam, Advocate Aurora HealthFollow

Document Type

Article

Language

eng

Publication Date

12-2020

Publisher

Elsevier

Source Publication

The Breast

Source ISSN

0960-9776

Abstract

Background

Due to its rarity, few studies have characterized the epidemiology of male breast cancer. The purpose of this study was to determine survival and risk factors for male breast cancer in a large U.S. population.

Methods

In this study, 19,795 male patients with breast cancer were identified from the National Cancer Database (2004–2014). Patient demographics, tumor characteristics and treatments were analyzed by using descriptive statistics. We used multivariate Cox regression and Kaplan Meier analysis.

Results

Over 10 years, the incidence of male breast cancer increased from 7.2% to 10.3%, while mortality decreased from 11% to 3.8%. Socioeconomic factors predicting mortality included income medium, and high vs low (HR = 0.78; 0.68), private vs no insurance (HR = 0.73) and the academic research facility vs community cancer center (HR = 0.79). Significant predictors of all-cause mortality included age (HR = 1.04), tumor size (HR = 1.01), hormone receptor expression (HR = 0.8) and cancer stage I vs II, III, and IV at the time of diagnosis (HR = 1.5, 2.7, 4.4, 9.9 respectively). Other predictors of mortality include surgery (HR = 0.4), chemotherapy (HR = 0.8), radiation (HR = 0.8), and hormonal therapy (HR-0.8).

Conclusions

Socioeconomic factors, cancer stage, tumor characteristics (size and grade), and high Charlson-Dayo score contributed to higher mortality among male patients diagnosed with breast cancer. Surgery was most effective, followed by radiation, chemotherapy, and hormonal therapy. Patients with positive ER or PR expression demonstrated better survival. Adjusting for socioeconomic factors, biomarker identification and timely, appropriately chosen treatment are likely to reduce the risk for mortality.

Comments

Accepted version. The Breast, Vol. 54, (December 2020): 8-14. DOI. © 2020 Elsevier. Used with permission.

Recommended Citation

Konduri, Santhi; Singh, Maharaj; Bobustuc, George; Rovin, Richard; and Kassam, Amin, "Epidemiology of Male Breast Cancer" (2020). School of Dentistry Faculty Research and Publications. 408.
https://epublications.marquette.edu/dentistry_fac/408