Document Type
Article
Publication Date
9-29-2020
Publisher
BioMed Central
Source Publication
Stem Cell Research & Therapy
Source ISSN
1757-6512
Abstract
Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes, fibroblasts, melanocytes, and inflammatory cells can secrete different types of EVs depending on their biological state. These vesicles can influence the physiological properties and pathological processes of skin, such as pigmentation, cutaneous immunity, and wound healing. Since keratinocytes constitute the majority of skin cells, secreted EVs from these cells may alter the pathophysiological behavior of other skin cells. This paper reviews the contents of keratinocyte-derived EVs and their impact on fibroblasts, melanocytes, and immune cells to provide an insight for better understanding of the pathophysiological mechanisms of skin disorders and their use in related therapeutic approaches.
Recommended Citation
Nasiri, Golara; Azarpira, Negar; Alizadeh, Aliakbar; Goshtasbi, Sanaz; and Tayebi, Lobat, "Shedding Light on The Role of Keratinocyte-Derived Extracellular Vesicles on Skin-Homing Cells" (2020). School of Dentistry Faculty Research and Publications. 425.
https://epublications.marquette.edu/dentistry_fac/425
Comments
Published version. Stem Cell Research & Therapy, Vol. 11 (September 29, 2020): 241. DOI. © 2020 BioMed Central (BMC). Used with permission.