Recent Advances in Porphyrin-Based Nanocomposites for Effective Targeted Imaging and Therapy

Authors

Navid Rabiee, Sharif University of Technology
Mohammad Tavakkoli Yaraki, National University of SingaporeFollow
Soha Mokhtari Garakani, Payame Noor University
Shima Mokhtari Garakani, Payame Noor University
Sepideh Ahmadi, Shahid Beheshti University of Medical SciencesFollow
Aseman Lajevardi, Islamic Azad University
Mojtaba Bagherzadeh, Sharif University of Technology
Mohammad Rabiee, Amirkabir University of Technology
Lobat Tayebi, Marquette UniversityFollow
Mohammadreza Tahriri, Marquette UniversityFollow
Michael R. Hamblin, Massachusetts General Hospital

Document Type

Article

Publication Date

2-2020

Publisher

Elsevier

Source Publication

Biomaterials

Source ISSN

0142-9612

Abstract

Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have been used to improve delivery characteristics. Porphyrins can be used in a composite designed material with properties that allow specific targeting, immune tolerance, extended tissue lifetime and improved hydrophilicity. Drug delivery, healing and repairing of damaged organs, and cancer theranostics are some of the medical uses of porphyrin-based nanocomposites covered in this review.

Comments

Accepted version. Biomaterials, Vol. 232 (February 2020): 119707. DOI. © 2020 Elsevier. Used with permission.

Recommended Citation

Rabiee, Navid; Yaraki, Mohammad Tavakkoli; Garakani, Soha Mokhtari; Garakani, Shima Mokhtari; Ahmadi, Sepideh; Lajevardi, Aseman; Bagherzadeh, Mojtaba; Rabiee, Mohammad; Tayebi, Lobat; Tahriri, Mohammadreza; and Hamblin, Michael R., "Recent Advances in Porphyrin-Based Nanocomposites for Effective Targeted Imaging and Therapy" (2020). School of Dentistry Faculty Research and Publications. 427.
https://epublications.marquette.edu/dentistry_fac/427