Document Type
Article
Publication Date
11-2020
Publisher
Wiley
Source Publication
International Journal of Applied Ceramic Technology
Source ISSN
1546-542x
Abstract
This research aims to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by ZnO for bone tissue engineering applications. HA and ZnO were developed using sol‐gel and precipitation methods respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), atomic absorption (AA), and atomic force microscopy (AFM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ZnO scaffolds possess higher compressive strength, fracture toughness, and density—but lower hardness—when compared to the pure HA scaffolds. After immersing the scaffold in the SBF solution, more deposited apatite appeared on the HA/ZnO, which results in the rougher surface on this scaffold compared to the pure HA scaffold. Finally, the in vitro biological analysis using human osteoblast cells reveals that scaffolds are biocompatible with adequate ALP activity.
Recommended Citation
Heidari, Fatemeh; Bazargan-Lari, Reza; Razavi, Mehdi; Fahimipour, Farahnaz; Vashaee, Daryoosh; and Tayebi, Lobat, "Nano-Hydroxyapatite and Nano-Hydroxyapatite/Zinc Oxide Scaffold for Bone Tissue Engineering Application" (2020). School of Dentistry Faculty Research and Publications. 431.
https://epublications.marquette.edu/dentistry_fac/431
Comments
Accepted version. International Journal of Applied Ceramic Technology, Vol. 17, No. 6 (November/December 2020): 2752-2761. DOI. © 2020 Wiley. Used with permission.