Document Type
Article
Publication Date
5-2020
Publisher
Dove Medical Press Limited
Source Publication
International Journal of Nanomedicine
Source ISSN
1176-9114
Abstract
Titanium dioxide (TiO2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies—like poor surface interaction with surrounding tissues—by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs—like osteoporosis drugs, anticancer and antibiotics—and used as local drug delivery systems. Furthermore, TiO2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO2 nanostructures, as well as its toxicity and biocompatibility, are presented.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Recommended Citation
Jafari, Sevda; Mahyad, Baharak; Hashemzadeh, Hadi; Janfaza, Sajjad; Gholikhani, Tooba; and Tayebi, Lobat, "Biomedical Applications of TiO2 Nanostructures: Recent Advances" (2020). School of Dentistry Faculty Research and Publications. 449.
https://epublications.marquette.edu/dentistry_fac/449
Comments
Published version. International Journal of Nanomedicine, Vol. 2020 (May 2020): 3447-3470. DOI. © 2020 Dove Medical Press Limited. Used with permission.