Document Type
Article
Publication Date
3-2021
Publisher
Wiley
Source Publication
Advanced Therapeutics
Source ISSN
2366-3987
Abstract
Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases. Although genetics, age, and environmental factors affect the disease, the cause of AD is not yet fully known. Various drugs have been proposed for the prevention and treatment of AD, but the delivery of these therapeutic agents to the brain is difficult. The blood–brain barrier prevents systemic drugs from accessing the central nervous system and designing a suitable system to overcome this barrier has attracted much attention. The intranasal pathway, given its proximity to the brain, provides a great opportunity for drug delivery. Understanding the physiological characteristics of the nose can be useful in selecting the appropriate carrier and material. Some of the emerging vehicles used for nose-to-brain delivery of anti-AD drugs are natural (such as chitosan) and polymeric (such as poly(lactic-co-glycolic acid) and polyethylene glycol) nanoparticles (NPs). This review discusses the hypotheses for AD pathogenesis and highlights recent advances in the applications of natural and polymeric NPs for treatment. The fundamental and applied aspects of this approach for nasal drug delivery to the brain are reviewed here with thoughts on what is needed for the field to mature also provided.
Recommended Citation
Rabiee, Navid; Ahmadi, Sepideh; Afshari, Ronak; Khalaji, Samira; Rabiee, Mohammad; Bagherzadeh, Mojtaba; Fatahi, Yousef; Dinarvand, Rassoul; Tahriri, Mohammadreza; Tayebi, Lobat; Hamblin, Michael R.; and Webster, Thomas J., "Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease" (2021). School of Dentistry Faculty Research and Publications. 490.
https://epublications.marquette.edu/dentistry_fac/490
Comments
Accepted version. Advanced Therapeutics, Vol. 4, No. 3 (March 2021): 2000076. DOI. © 2021 Wiley. Used with permission.