Document Type
Article
Publication Date
7-2005
Publisher
Elsevier
Source Publication
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Source ISSN
2212-4403
Original Item ID
DOI: 10.1016/j.tripleo.2005.01.017
Abstract
The epithelioid cell histiocytoma (ECH) is a polypoidal benign tumor of superficial connective tissue that is often diagnosed as a pyogenic granuloma. ECHs are speculated to originate from dermal dendritic subunits and are composed of 2 primary cell populations, ie, CD34+ primitive fibroblastic dendrocytes and factor XIIIa+ histiocytes. Although dendritic subunits are distributed throughout most collagenous tissues inclusive of oral mucosa, to date, all reported cases of ECH have been cutaneous lesions. ECHs' putative pathogenesis entails activation of CD34+ “sentinel” reserve dendrocytes, followed by an influx of histiocytes and mast cells. Juxtacrine communication increases release of wound healing factors; suggesting a reactive etiologic component. In this current case, the location (ventral tongue) and history (recent increase in size) suggest the possibility that trauma could have initiated the dendritic subunit “wound healing” cascade. Consistent with its benign course, the ECH is managed by local excision, and has an excellent prognosis.
Recommended Citation
Rawal, Yeshwant B.; Kalmar, John R.; Shumway, Brian S.; and Mallery, Susan R., "Presentation of an Epithelioid Cell Histiocytoma on the Ventral Tongue" (2005). School of Dentistry Faculty Research and Publications. 537.
https://epublications.marquette.edu/dentistry_fac/537
Comments
Accepted version. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 100, No. 1 (July 2005): 75-83. DOI. © Elsevier. Used with permission.
Yeshwant B. Rawal was affiliated with The Ohio State University at the time of publication.