Document Type
Article
Publication Date
6-2004
Publisher
Elsevier
Source Publication
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Source ISSN
2212-4403
Original Item ID
DOI: 10.1016/j.tripleo.2003.11.017
Abstract
Post-irradiation sarcoma is a well-defined complication of radiation therapy, yet few reports document such lesions in the head and neck. A 30-year-old man presented for evaluation of an expansile lesion of the left posterior maxilla. His medical history was significant for a childhood ocular malignancy - unilateral retinoblastoma - which was treated with a combination of surgical enucleation of the eye and external beam radiation therapy. Biopsy of his maxillary lesion revealed a spindle cell malignancy that was morphologically and immunohistochemically consistent with a diagnosis of leiomyosarcoma. Further investigation into the case revealed that the patient had three children, every one of whom developed unilateral retinoblastoma in infancy. Compared to the more frequent presentation of bilateral tumors in hereditary cases of retinoblastoma, such cases of heritable unilateral retinoblastoma are exceptional. Importantly, heritable forms of retinoblastoma confer a significant risk for development of second primary cancers, necessitating long-term clinical follow-up in these patients.
Recommended Citation
Sedghizadeh, Parish P.; Angiero, Francesca; Allen, Carl M.; Kalmar, John R.; Rawal, Yeshwant B.; and Albright, Eric A., "Post-irradiation Leiomyosarcoma of the Maxilla: Report of a case in a Patient with Prior Radiation Treatment for Retinoblastoma" (2004). School of Dentistry Faculty Research and Publications. 540.
https://epublications.marquette.edu/dentistry_fac/540
Comments
Accepted version. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 97, No. 6 (June 2004): 726-731. DOI. © 2004 Elsevier. Used with permission.