Intra-Marrow Penetrations and Root Coverage Outcomes: A Systematic Review

Authors

Vrisiis Kofina, Marquette UniversityFollow
Ving Wang, The Ohio State University
Alissa V. Fial, Marquette UniversityFollow
Dimitris N. Tatakis, The Ohio State University

Document Type

Article

Publication Date

2023

Publisher

BioMed Central

Source Publication

BMC Oral Health

Source ISSN

1472-6831

Original Item ID

DOI: 10.1186/s12903-023-02964-6

Abstract

Background

Intra-marrow penetrations (IMPs) have been performed during guided tissue regeneration (GTR) procedures with reported clinical benefits. The aim of this systematic review was to investigate the use and effect of IMPs during root coverage procedures.

Method

A broad search for human and animal studies was performed on PubMed, Cochrane Database of Systematic Reviews and Cochrane Central Registry of Controlled Trials and Web of Science, following a registered review protocol (PROSPERO). All prospective study designs, case series and case reports on gingival recession treatment (follow-up ≥ 6 months) that employed IMPs were included. Root coverage, complete root coverage prevalence, and adverse effects were recorded, and risk of bias was assessed.

Results

Of 16,181 screened titles, 5 articles (all of them human studies) met inclusion criteria. All studies (including two randomized clinical trials) treated Miller class I and II recession defects, using coronally advanced flap with IMPs alone or in conjunction with GTR protocols. Therefore, all treated defects received IMPs and no studies compared protocols with and without IMPs. Outcomes were indirectly compared with existing root coverage literature. Mean root coverage was 2.7 mm and 68.5% at 6.8 months (median: 6 months, range 6–15 months) for sites treated with IMPs.

Conclusion

IMPs are rarely used during root coverage procedures, have not been associated with intra-surgical or wound healing adverse effects and have not been investigated as independent factor. Future clinical studies are needed to directly compare treatment protocols with and without IMPs and investigate the potential benefits of IMPs for root coverage.

Comments

Published version. BMC Oral Health, Vol. 23, No. 256 (2023). DOI. © 2023 BioMed Central (BMC). Used with permission.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Kofina, Vrisiis; Wang, Ving; Fial, Alissa V.; and Tatakis, Dimitris N., "Intra-Marrow Penetrations and Root Coverage Outcomes: A Systematic Review" (2023). School of Dentistry Faculty Research and Publications. 554.
https://epublications.marquette.edu/dentistry_fac/554