Mandibular Condylar Hyperplasia and Its Correlation with Vascular Endothelial Growth Factor

Document Type

Article

Publication Date

9-2023

Publisher

Wiley

Source Publication

Journal of Oral Rehabilitation

Source ISSN

0305-182X

Original Item ID

DOI: 10.1111/joor.13487

Abstract

Background

Condylar hyperplasia (CH) is a rare condition characterised by excessive unilateral growth of the mandibular condyle after cessation of growth on the contralateral side causing facial asymmetry, being more prevalent in the second and third decades.

Objective

The aim of this study was to determine the utility of vascular endothelial growth factor (VEGF-A) as a diagnostic and prognostic factor in condylar hyperplasia, and to determine its potential viability as a therapeutic target.

Methods

This is a case–control study, where 17 mandibular condyles specimens were collected from 17 patients treated for active mandibular condyle hyperplasia and three unaffected human mandibular condyles from cadavers will serve as the control group. The samples were immunostained with VEGF-A antibody and evaluated on both quantity and intensity of staining.

Results

VEGF-A was qualitatively found to be greatly upregulated in patients with condylar hyperplasia.

Conclusion

VEGF-A was qualitatively found to be upregulated in patients affected by CH, validating VEGF-A as a potential diagnostic, prognostic and therapeutic target.

Comments

Journal of Oral Rehabilitation, Vol. 50, No. 9 (September 2023): 845-851. DOI.

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