Date of Award
Spring 2008
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Sem, Daniel
Second Advisor
Ryan, Michael
Third Advisor
Hossenlopp, Jeanne M.
Abstract
Kinases catalyze the transfer of the y phosphate of adenosine triphosphate (ATP) to a substrate. They can phosphorylate either "small molecules" or proteins, playing important roles in metabolism and regulation, respectively. A conserved aspartate in the active site acts as a general base, which deprotonates the substrate nucleophile that attacks the y phosphate. Small molecule kinases phosphorylate non-protein substrates like glucose, pyruvate and other metabolites...
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