Date of Award

Spring 2008

Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)



First Advisor

Sem, Daniel

Second Advisor

Ryan, Michael

Third Advisor

Hossenlopp, Jeanne M.


Kinases catalyze the transfer of the y phosphate of adenosine triphosphate (ATP) to a substrate. They can phosphorylate either "small molecules" or proteins, playing important roles in metabolism and regulation, respectively. A conserved aspartate in the active site acts as a general base, which deprotonates the substrate nucleophile that attacks the y phosphate. Small molecule kinases phosphorylate non-protein substrates like glucose, pyruvate and other metabolites...



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