Date of Award
5-1971
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Medical
First Advisor
Alvin F. Rieck
Second Advisor
D.W. Glenister
Third Advisor
H.M. Klitgaard
Fourth Advisor
W.J. Stekiel
Fifth Advisor
K.E. Whisler
Abstract
The purpose of this dissertation was to compare the responses of normal and 'adapted," i.e. high glutaminase I activity, rats to both acute and chronic administration of an acid load. The rats were "adapted" by substituting 1.5 per cent ammonium chloride for drinking water for six days and 1.5 per cent sodium chloride or one day. These animals had normal ammonia excretion rates but their glutaminase I activities were three times greater than control values.
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