Ammonia Excretion Rate and Renal Glutaminase I Activity During Acute and Chronic Metabolic Acidosis in the Rat
Date of Award
Dissertation - Restricted
Doctor of Philosophy (PhD)
Alvin F. Rieck
The purpose of this dissertation was to compare the responses of normal and 'adapted," i.e. high glutaminase I activity, rats to both acute and chronic administration of an acid load. The rats were "adapted" by substituting 1.5 per cent ammonium chloride for drinking water for six days and 1.5 per cent sodium chloride or one day. These animals had normal ammonia excretion rates but their glutaminase I activities were three times greater than control values.