Date of Award
6-1972
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Medical
First Advisor
Joseph J. Barboriak
Second Advisor
James M. Fujimoto
Third Advisor
Deane N. Calvert
Fourth Advisor
John J. Lech
Fifth Advisor
Harold P. Hardman
Abstract
Recently, it has been suggested that ethanol may also enhance the drug-metabolizing enzyme system (Rubin and Lieber, 1968) and that enhancement of this enzyme system by other inducers may increase ethanol metabolism (Wooles and Weymouth, 1968). The role of the microsomal drug-metabolizing enzyme system in ethanol metabolism has been complicated by recent reports that ethanol is metabolized by a separate, microsomal enzyme system specific for this agent (Lieber and DeCarli, 1968). Since agents which enhance ethanol metabolism may be of considerable practical importance and the reported findings to this effect were of an acute nature, we decided to investigate whether and to what extent a long-term administration of some of the inducers of the microsomal drug-metabolizing enzyme system affects ethanol metabolism, be it by the conventional drug-metabolizing enzyme system or by the already mentioned specific microsomal pathway.