Date of Award
12-1977
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Biological Sciences
First Advisor
Oliver H. Smith
Second Advisor
James R. Hutton
Third Advisor
Sally Hennen
Fourth Advisor
James B. Courtright
Fifth Advisor
Walter W. Fredricks
Abstract
Genetic regulatory control mechanisms are necessary for the normal proliferation and survival of cells. These control mechanisms have been, and are currently being, intensively investigated. Much of our current knowledge in this area of research has been derived from studies of the bacterium Escherichia coli. The ability, or inability, of various strains of E. coli to express a particular phenotype under experimentally-defined growth conditions has led to the elucidation of many control mechanisms that regulate specific gene expression.
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