Date of Award


Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)


Biological Sciences

First Advisor

Oliver H. Smith

Second Advisor

James R. Hutton

Third Advisor

Sally Hennen

Fourth Advisor

James B. Courtright

Fifth Advisor

Walter W. Fredricks


Genetic regulatory control mechanisms are necessary for the normal proliferation and survival of cells. These control mechanisms have been, and are currently being, intensively investigated. Much of our current knowledge in this area of research has been derived from studies of the bacterium Escherichia coli. The ability, or inability, of various strains of E. coli to express a particular phenotype under experimentally-defined growth conditions has led to the elucidation of many control mechanisms that regulate specific gene expression.



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