Date of Award
8-1977
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Biological Sciences
First Advisor
Peter Abramoff
Second Advisor
Jordan Fink
Third Advisor
Walter Fredricks
Fourth Advisor
Vernon Moore
Fifth Advisor
Ellen Rasch
Abstract
It has become increasingly apparent that immune complexes (antigen-antibody complexes) play an important role in the pathogenesis of a variety of human diseases, e.g. glomerulonephritis, vasculitis and endocarditis. Studies on the pathogenesis of immune-complex disease began in 1905 with the observations of von Pirquet and Schick (1). They recognized the relationship between the host's immune response to foreign serum protein and the development of serum sickness. The disease usually began 8 to 12 days after the therapeutic administration of foreign serum and was characterized by urticaria, fever, edema, neutropenia and lymph node enlargement.
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