Date of Award


Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)


Biological Sciences

First Advisor

Peter Abramoff

Second Advisor

Jordan Fink

Third Advisor

Walter Fredricks

Fourth Advisor

Vernon Moore

Fifth Advisor

Ellen Rasch


It has become increasingly apparent that immune complexes (antigen-antibody complexes) play an important role in the pathogenesis of a variety of human diseases, e.g. glomerulonephritis, vasculitis and endocarditis. Studies on the pathogenesis of immune-complex disease began in 1905 with the observations of von Pirquet and Schick (1). They recognized the relationship between the host's immune response to foreign serum protein and the development of serum sickness. The disease usually began 8 to 12 days after the therapeutic administration of foreign serum and was characterized by urticaria, fever, edema, neutropenia and lymph node enlargement.




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