"Mesenteric Hemodynamics and Shock Protection after Splanchnic Adrenerg" by Dennis L. Murphy
 

Date of Award

5-1963

Degree Type

Master's Essay - Restricted

Degree Name

Master of Science (MS)

Department

Biological Sciences

First Advisor

James J. Smith

Abstract

The discovery end delineation within the past decade of drugs capable of o^adrenergic blockade have provided a new tool for the reinvestigation of adrenergic activity and vasoconstriction in shock. The prominence of the clinical signs in shock resulting from epinephrine and adrenergic neural activity have excited debate for almost fifty years over whether these effects are compensatory and homeostatic—especially when present for a long duration—or whether they are deleterious. The question is particularly critical because vasoconstricting agents remain the usual treatment for shock in the clinical practice of medicine, even though the long term effects of preferentially maintaining blood pressure rather than blood flow are unknown.

The present study is an investigation of the effects of an adrenergic blocking agent, phenoxybenzamine, on blood flow in the peripheral vascular bed of the splanchnic region before and during hemorrhage-induced hypotension and shock. It was initiated to assess the possible protective effects of blocking vasoconstriction in a vascular bed postulated as critical in the pathogenesis of shock, and in this way, perhaps, to define the importance of adrenergic activity in the splanchnic area as compensatory or deleterious in shock.

Comments

A Thesis submitted to the Faculty of the Graduate School, Marquette University in Partial Fulfillment of the Requirements for the Degree of Master of Science in Physiology, Milwaukee, Wisconsin

Download

Share

COinS