"The Changes in the Serum Protein Concentration Associated with Water D" by Willerd H. Spankus
 

Date of Award

8-1949

Degree Type

Master's Essay - Restricted

Degree Name

Master of Science (MS)

Department

Medical

First Advisor

Maurice Hardgrove

Abstract

The original intent of this study was to determine whether any abnormality of blood dilution occurred during the "Kepler Test" in patients with Addison's Disease. It was hoped that the observations on the pattern of blood dilution that occurred in these cases would indicate the cause for the impaired diuretic response to water that exists in adrenal cortical insufficiency. After preliminary studies the scope of the investigation was widened for two reasons: The first was the paucity of available subjects with Addison's Disease; the second, and more important reason, was the realization that to avoid false conclusions concerning the relationship of the adrenal gland to changes in the composition of blood after water ingestion one would have to compare these changes with similar; studies on patients presenting various types of diseases. Although forty patients were studied, many of whom demonstrated impaired water diuresis, it was of interest that the most significant findings noted in the study were made in the group of patients with adrenal cortex insufficiency.

Comments

Thesis submitted for the Degree of Master of Science 1n Internal Medicine, Marquette University, Milwaukee, Wisconsin.

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