Date of Award
5-1960
Degree Type
Master's Essay
Degree Name
Master of Science (MS)
Department
Medical
First Advisor
Howard M. Klitgaard
Second Advisor
William J. Stekiel
Abstract
The intellectual calm that prevailed in thyroid physiology on the basis of the concept that thyroxine was the thyroid hormone, was upset by the discovery and characterization of a new thyroid hormone in 1951 and 1952. In a brilliant series of experiments this new sub¬ stance, triiodothyronine, was found to be more potent and its action more rapid than thyroxine. Such observations had a salutary effect on thyroid physiology and stimulated a ferment of investigation of far-reaching consequence. Other thyroactive analogues of thyroxine and triiodothyronine have since been studied in an effort to elucidate the nature and mode of action of the thyroid hormone or hormones. There¬ fore it was considered feasible to analyze rat tissues for these products after the animals were injected with thyroxine to see if there were any correlation of these substances with known oxygen consumption values. It is felt that such a study has intrinsic value as it will help to delineate the nature of the hormone acting at the tissue level and provide some insight into the complexities of pinpointing the thyroid hormones’ mode of action.
Recommended Citation
Mullooly, John P., "A Chromatographic, Autoradiographic and Actigraphic Analysis of Thyroxine Metabolites in Rat Tissues and Their Correlation With Oxygen Consumption Values" (1960). Master's Essays (1922 - ). 2955.
https://epublications.marquette.edu/essays/2955
Comments
A Thesis submitted to the Faculty of the Graduate School, Marquette University in Partial Fulfillment of the Requirements for the Degree of Master of Science, Milwaukee, Wisconsin