Toward Translating Near-Infrared Spectroscopy Oxygen Saturation Data for The Non-Invasive Prediction of Spatial and Temporal Hemodynamics During Exercise

Authors

Laura M. Ellwein, Marquette UniversityFollow
Margaret M. Samyn, Marquette UniversityFollow
Michael E. Danduran, Marquette UniversityFollow
Sheila M. Schindler-Ivens, Marquette UniversityFollow
Stacy Liebham, Children's Hospital of Wisconsin, Wauwautosa, WI
John F. LaDisa Jr., Marquette UniversityFollow

Document Type

Article

Language

eng

Format of Original

22 p.

Publication Date

7-4-2016

Publisher

Springer

Source Publication

Biomechanics and Modeling in Mechanobiology

Source ISSN

1617-7959

Abstract

Image-based computational fluid dynamics (CFD) studies conducted at rest have shown that atherosclerotic plaque in the thoracic aorta (TA) correlates with adverse wall shear stress (WSS), but there is a paucity of such data under elevated flow conditions. We developed a pedaling exercise protocol to obtain phase contrast magnetic resonance imaging (PC-MRI) blood flow measurements in the TA and brachiocephalic arteries during three-tiered supine pedaling at 130, 150, and 170 % of resting heart rate (HR), and relate these measurements to non-invasive tissue oxygen saturation (StO₂) acquired by near-infrared spectroscopy (NIRS) while conducting the same protocol. Local quantification of WSS indices by CFD revealed low time-averaged WSS on the outer curvature of the ascending aorta and the inner curvature of the descending aorta (dAo) that progressively increased with exercise, but that remained low on the anterior surface of brachiocephalic arteries. High oscillatory WSS observed on the inner curvature of the aorta persisted during exercise as well. Results suggest locally continuous exposure to potentially deleterious indices of WSS despite benefits of exercise. Linear relationships between flow distributions and tissue oxygen extraction calculated from StO₂ were found between the left common carotid versus cerebral tissue (r² = .96) and the dAo versus leg tissue (r² = .87). A resulting six-step procedure is presented to use NIRS data as a surrogate for exercise PC-MRI when setting boundary conditions for future CFD studies of the TA under simulated exercise conditions. Relationships and ensemble-averaged PC-MRI inflow waveforms are provided in an online repository for this purpose.

Comments

Accepted version. Biomechanics and Modeling in Mechanobiology, Vol. 16, No. 1 (February 2017): 75-96. DOI. © 2017 Springer. Used with permission.

Recommended Citation

Ellwein, Laura M.; Samyn, Margaret M.; Danduran, Michael E.; Schindler-Ivens, Sheila M.; Liebham, Stacy; and LaDisa, John F. Jr., "Toward Translating Near-Infrared Spectroscopy Oxygen Saturation Data for The Non-Invasive Prediction of Spatial and Temporal Hemodynamics During Exercise" (2016). Exercise Science Faculty Research and Publications. 101.
https://epublications.marquette.edu/exsci_fac/101