Effect of Chronic Renal Medullary Nitric Oxide Inhibition on Blood Pressure.

Document Type

Article

Language

eng

Publication Date

5-1994

Publisher

American Physiological Society

Source Publication

American Journal of Physiology - Heart and Circulatory Physiology

Source ISSN

0002-9513

Abstract

The effects of chronic nitric oxide inhibition in the renal medulla on renal cortical and medullary blood flow, sodium balance, and blood pressure were evaluated in conscious uninephrectomized Sprague-Dawley rats. During a 5-day renal medullary interstitial infusion of the nitric oxide inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 120 micrograms/h) in saline (0.5 ml/min), renal medullary blood flow was selectively decreased by 30% after 2 h and was maintained at that level for the entire infusion. The decrease in medullary blood flow was associated with sodium retention and increased blood pressure. After the cessation of L-NAME infusion, medullary blood flow returned to control, and the sodium balance became negative as blood pressure returned to baseline. These data indicate that renal medullary nitric oxide plays an important role in the regulation of renal blood flow, sodium excretion, and blood pressure.

Comments

American Journal of Physiology - Heart and Circulatory Physiology, Vol. 266, No. 5 (May 1994): H1918-H1926. DOI.

Paula Papanek was affiliated with Medical College of Wisconsin at the time of publication.

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