Effects of sprint training on extrarenal potassium regulation with intense exercise in Type 1 diabetes

Authors

Alison R. Harmer, University of Sydney
Patricia A. Ruell, University of Sydney
Michael J. McKenna, Victoria University of Technology
Donald J. Chisholm, The Garvan Institute of Medical Research
Sandra K. Hunter, Marquette UniversityFollow
Jeanette M. Thom, University of Sydney
Norman R. Morris, University of Sydney
Jeff R. Flack, Bankstown-Lidcombe Hospital

Document Type

Article

Language

eng

Format of Original

9 p.

Publication Date

1-2006

Publisher

American Physiological Society

Source Publication

Journal of Applied Physiology

Source ISSN

0021-8987

Original Item ID

DOI: 10.1152/japplphysiol.00240.2005

Abstract

Effects of sprint training on plasma K⁺ concentration ([K⁺]) regulation during intense exercise and on muscle Na⁺-K⁺-ATPase were investigated in subjects with Type 1 diabetes mellitus (T1D) under real-life conditions and in nondiabetic subjects(CON). Eight subjects with T1D and seven CON undertook 7 wk of sprint cycling training. Before training, subjects cycled to exhaustion at 130% peak O₂ uptake. After training, identical work was performed. Arterialized venous blood was drawn at rest, during exercise, and at recovery and analyzed for plasma glucose, [K⁺], Na⁺ concentration ([Na⁺]), catecholamines, insulin, and glucagon. A vastus lateralis biopsy was obtained before and after training and assayed for Na⁺-K⁺-ATPase content ([³H]ouabain binding). Pretraining, Na⁺-K⁺-ATPase content and the rise in plasma [K⁺] (Δ[K⁺]) during maximal exercise were similar in T1D and CON. However, after 60 min of recovery in T1D, plasma [K⁺], glucose, and glucagon/insulin were higher and plasma [Na⁺] was lower than in CON. Training increased Na⁺-K⁺-ATPase content and reduced Δ[K⁺] in both groups (P < 0.05). These variables were correlated in CON (r = –0.65, P < 0.05) but not in T1D. This study showed first that mildly hypoinsulinemic subjects with T1D can safely undertake intense exercise with respect to K⁺ regulation; however, elevated [K⁺] will ensue in recovery unless insulin is administered. Second, sprint training improved K⁺ regulation during intense exercise in both T1D and CON groups; however, the lack of correlation between plasma Δ[K⁺] and Na⁺-K⁺-ATPase content in T1D may indicate different relative contributions of K⁺-regulatory mechanisms.

Comments

Journal of Applied Physiology, Vol. 100, No. 1 (January 2006): 26-34. DOI.

Recommended Citation

Harmer, Alison R.; Ruell, Patricia A.; McKenna, Michael J.; Chisholm, Donald J.; Hunter, Sandra K.; Thom, Jeanette M.; Morris, Norman R.; and Flack, Jeff R., "Effects of sprint training on extrarenal potassium regulation with intense exercise in Type 1 diabetes" (2006). Exercise Science Faculty Research and Publications. 6.
https://epublications.marquette.edu/exsci_fac/6