Title
Stimulation of interleukin-1 and -6 production in alveolar macrophages by neotropical liana, Uncaria tomentosa (Uña de Gato)
Document Type
Article
Publication Date
1999
Volume Number
64
Source Publication
Journal of Ethnopharmacology
Abstract
Two extracts of different collections of the traditional medicine uña de gato (Uncaria tomentosa) from Peru were characterized by High Pressure Liquid Chromatography as containing approximately 6 mg/g total oxindole content prior to studies with alveolar macrophages. The plant preparations greatly stimulated IL-1 and IL-6 production by rat macrophages in a dose dependent manner in the range of 0.025–0.1 mg/ml. They were also able to enhance IL-1 and -6 in lipopolysaccharide-stimulated macrophages. The results suggest a strong immunostimulant action of this plant.
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