Document Type

Article

Publication Date

1-2026

Publisher

Elsevier

Source Publication

Acta Biomaterialia

Source ISSN

1742-7061

Abstract

The permanent nature of bare metal and drug eluting stents can lead to serious long-term complications such as neoatherosclerosis and late stent thrombosis. Magnesium (Mg) based bioabsorbable metal stents, with the ability to provide temporary support to stenosed arteries and harmlessly degrade, are in position to be the 4th revolution of interventional cardiology. Mg materials are known to be sensitive to biological factors, however this has been understudied with respect to hyperlipidemia. In this study, two distinct WE-series (Mg-Y-Nd) alloy wires (WE43 and WE22) were implanted into the abdominal aorta of wild-type and hyperlipidemic apolipoprotein E knockout (ApoE-/-) mice for 10 days to investigate the acute corrosion response. We report increased corrosion in ApoE-/- mice for both alloys, resulting in wire breakage for 50% of WE43 (n=4) and 75% of WE22 implants (n=4) in ApoE-/- mice compared to 0% in wild-type mice for each alloy (n = 4 WE43 and n=4 WE22). Additionally, human low- and high-density (LDL/HDL) lipoproteins were used to study the in vitro corrosion behavior of WE-series alloys. We report increased acute corrosion of WE43 (6.2 ± 0.7 mm/yr in lipoprotein-supplemented DMEM vs 1.5 ± 0.3 mm/yr in DMEM) and decreased Ca and Mg in the oxide layer of wires corroded in lipoprotein-supplemented medium. Here, LDL and HDL are shown to impact Mg alloy biocorrosion in a dose- and species-dependent manner. Based on our observations, we propose a general mechanism for lipoprotein-mediated Mg corrosion driven by differential chelation of alloying elements specific to each lipoprotein species.

Comments

Accepted version. Acta Biomaterialia, Vol. 213 (2026): 791-804. DOI. © 2026 Elsevier. Used with permission.

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