Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder

Authors

• Crista Ulteig, Advocate Aurora Health
• Kristin Ciezki, Advocate Aurora Health
• Megan Jacobson, Advocate Aurora Health
• Maharaj Singh, Marquette UniversityFollow
• Tarun Sharma, University of Wisconsin School of Medicine and Public Health

Document Type

Article

Publication Date

1-2022

Publisher

Lippincott Williams & Wilkins, Inc.

Source Publication

ACG Case Reports Journal

Source ISSN

2326-3253

Abstract

Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well documented. We report a case series of 3 patients with coexisting esophageal dysmotility and constipation on chronic opioids that improved both symptoms after starting naloxegol. Based on these observational studies, we propose that formal studies be conducted to assess the effect of naloxegol on opioid-induced esophageal dysmotility.

Comments

Accepted version. ACG Case Reports Journal, Vol. 9, No. 1 (January 2022). DOI. © 2022 The Authors, published by Wolters Kluwer Health, Inc. Used with permission.

Recommended Citation

Ulteig, Crista; Ciezki, Kristin; Jacobson, Megan; Singh, Maharaj; and Sharma, Tarun, "Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder" (2022). College of Nursing Faculty Research and Publications. 1161.
https://epublications.marquette.edu/nursing_fac/1161