Hypertrophic Cardiomyopathy With Aortic Dilation: A Novel Observation

Authors

• Ryan Yousefzai, University of Wisconsin School of Medicine and Public Health
• Anushree Agarwal, University of Wisconsin School of Medicine and Public Health
• M. Fuad Jan, University of Wisconsin School of Medicine and Public Health
• Chi Cho, University of Wisconsin School of Medicine and Public Health
• Michael Anigbogu, University of Wisconsin School of Medicine and Public Health
• Kambiz Shetabi, University of Wisconsin School of Medicine and Public Health
• Maharaj Singh, Marquette UniversityFollow
• Michelle Bush, University of Wisconsin School of Medicine and Public Health
• Shannon Treiber, University of Wisconsin School of Medicine and Public Health
• Steven Port, University of Wisconsin School of Medicine and Public Health
• Khawaja Afzal Ammar, University of Wisconsin School of Medicine and Public Health
• Timothy E. Paterick, University of Wisconsin School of Medicine and Public Health
• Renuka Jain, University of Wisconsin School of Medicine and Public Health
• Bijoy K. Khandheria, University of Wisconsin School of Medicine and Public Health
• A. Jamil Tajik, Aurora St. Luke’s Medical School

Document Type

Article

Publication Date

12-2017

Publisher

Oxford University Press

Source Publication

European Heart Journal - Cardiovascular Imaging (EHJ-CVI)

Source ISSN

2047-2404

Abstract

Aims Our goal was to identify the prevalence of aortic dilation in patients with hypertrophic cardiomyopathy (HCM), the most prevalent (0.2%) heritable, genetic cardiovascular disease. Aortic dilation also represents a spectrum of familial inheritance. However, data regarding the prevalence of aortic dilation in HCM patients is lacking. Methods and results This is an observational retrospective study of all patients referred to our HCM centre. Aortic dilation was defined based on recent American Society of Echocardiography and European Association of Cardiovascular Imaging published guidelines. Of the 201 HCM patients seen between Jan. 1, 2011 and March 31, 2014, 18 (9.0%) met the definition of aortic dilation. Mean age was 56.3 ± 9.3 years, 77.8% were male, mean ascending aorta diameter was 4.0 ± 0.4 cm in males and 3.8 ± 0.2 cm in females, mean sinuses of Valsalva diameter was 4.2 ± 0.2 cm in males and 3.8 ± 0.4 cm in females, and 13 (72.2%) had left ventricular outflow tract obstruction. HCM patients with dilated aorta were more likely males, less likely hypertensive and had larger left ventricle diameter and more aortic valve regurgitation; remaining characteristics were similar. Conclusion We report a novel observation with 9.0% prevalance of dilated aorta in HCM patients. Further studies are needed to help define the genetic and pathophysiologic basis as well as the clinical implications of this association in a larger group of HCM patients.

Comments

Accepted version. European Heart Journal – Cardiovascular Imaging, Vol. 18, No. 12 (December 2017): 1398-1403. DOI. This article is © 2017 The Authors. Used with permission.

Recommended Citation

Yousefzai, Ryan; Agarwal, Anushree; Jan, M. Fuad; Cho, Chi; Anigbogu, Michael; Shetabi, Kambiz; Singh, Maharaj; Bush, Michelle; Treiber, Shannon; Port, Steven; Ammar, Khawaja Afzal; Paterick, Timothy E.; Jain, Renuka; Khandheria, Bijoy K.; and Tajik, A. Jamil, "Hypertrophic Cardiomyopathy With Aortic Dilation: A Novel Observation" (2017). College of Nursing Faculty Research and Publications. 1236.
https://epublications.marquette.edu/nursing_fac/1236