Document Type

Article

Language

eng

Format of Original

9 p.

Publication Date

2011

Publisher

Elsevier

Source Publication

Trends in Molecular Medicine

Source ISSN

1471-499X

Original Item ID

doi: 10.1016/j.molmed.2011.02.004

Abstract

Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has a vastly reduced genetic variation compared with humans; this simplifies disease mapping and pharmacogenomics. Dogs age five- to eight-fold faster than do humans, share environments with their owners, are usually kept until old age and receive a high level of health care. Farseeing investigators recognized this potential and, over the past decade, have developed the necessary tools and infrastructure to utilize this powerful model of human disease, including the sequencing of the dog genome in 2005. Here, we review the nascent convergence of genetic and translational canine models of spontaneous disease, focusing on cancer.

Comments

Accepted version. Trends in Molecular Medicine, Vol. 17, No. 7 (2011): 380-388. DOI. © 2011 Elsevier. Used with permission.

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