Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

2-28-2011

Publisher

Elsevier

Source Publication

Life Sciences

Source ISSN

0024-3205

Original Item ID

doi: 10.1016/j.lfs.2010.12.010

Abstract

Aims

Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease. In rodents, tumor-induced fatigue is associated with a progressive loss of skeletal muscle mass and increased expression of biomarkers of muscle protein degradation. The purpose of the present study was to determine if muscle wasting and expression of biomarkers of muscle protein degradation occur in the hearts of tumor-bearing mice, and if these effects of tumor growth are associated with changes in cardiac function.

Main methods

The colon26 adenocarcinoma cell line was implanted into female CD2F1 mice and skeletal muscle wasting, in vivo heart function, in vitro cardiomyocyte function, and biomarkers of muscle protein degradation were determined.

Key findings

Expression of biomarkers of protein degradation were increased in both the gastrocnemius and heart muscle of tumor-bearing mice and caused systolic dysfunction in vivo. Cardiomyocyte function was significantly depressed during both cellular contraction and relaxation.

Significance

These results suggest that heart muscle is directly affected by tumor growth, with myocardial function more severely compromised at the cellular level than what is observed using echocardiography.

Comments

Accepted version. Life Sciences, Vol. 88, No. 9-10 (February 28, 2011): 406-410. DOI. © 2011 Elsevier. Used with permission.

Donna McCarthy was affiliated with The Ohio State University at the time of publication.

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