Short Term Regulation of Energy Intake is Intact in Hypophagic Tumor-Bearing Rats

Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

10-1997

Publisher

Wiley

Source Publication

Research in Nursing and Health

Source ISSN

0160-6891

Original Item ID

doi: 10.1002/(SICI)1098-240X(199710)20:5<425::AID-NUR6>3.0.CO;2-Q; Shelves: RT1 .R48x Raynor Memorial Periodicals

Abstract

Anorexia and weight loss are major problems in the care of cancer patients. Data from laboratory studies using an animal model of tumor-induced anorexia suggest that energy intake may be regulated in the tumor-bearing host as it is in healthy animals. The purpose of the present study was to determine if hypophagic tumor-bearing rats would alter their food intake in response to manipulations known to affect food intake in normal healthy animals. Both tumor-bearing and healthy animals increased their food intake when housed at 22 versus 258° C and reduced their food intake when injected with anorexigenic doses of bacterial lipopolysaccharide or interleukin-1 alpha. These data suggest that selected physiological responses affecting short-term food intake are intact in the hypophagic tumor bearing host. © 1997 John Wiley & Sons, Inc. Res Nurs Health 20: 425–429, 1997

Comments

Research in Nursing and Health, Vol. 20, No. 5 (October 1997): 425-429. DOI.

Donna McCarthy was affiliated with the University of Wisconsin - Madison at the time of publication.

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