The Effects of Cyclooxygenase Inhibitors on Tumor-Induced Anorexia in Rats

Document Type

Article

Publication Date

1-15-1993

Publisher

Wiley

Source Publication

Cancer

Source ISSN

0008-543X

Original Item ID

DOI: 10.1002/1097-0142(19930115)71:2<486::AID-CNCR2820710233>3.0.CO;2-A

Abstract

Background. Interleukin-1 (IL-1) and tumor necrosis factor (TNF) are potent induces of prostaglandin (PG) synthesis and injection of PGE, IL-1, or TNF decreases food intake in healthy animals, whereas the anorexigenic effects of injected IL-1 and TNF are blocked by inhibitors of PG synthesis. It has been hypothesized that host secretion of IL-1 and TNF contribute to tumor-induced anorexia. This study was undertaken to determine whether administration of PG inhibitors alters food intake in anorectic rats implanted with Walker 256 carcinoma.

Methods. Groups of six tumor-bearing rats were implanted with slow-release pellets containing ibuprofen, indomethacin, or acetylsalicylic acid. Food intake, tumor growth, and body temperature were monitored for 14 days and compared with control tumor-bearing animals implanted with placebo pellets.

Results. Tumor growth was associated with anorexia, fever, weight loss, and increased leukocyte secretion of IL-1 and TNF. Indomethacin and ibuprofen retarded tumor growth 30–40% and lowered body temperature compared with controls, but had no effect on food intake or body weight of tumor-bearing animals.

Conclusions. Prostaglandins do not mediate tumor-induced anorexia.

Comments

Cancer, Vol. 71, No. 2 (January 15, 1993): 486-492. DOI.

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